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"The findings of our study have important implications since ischaemic concentrations of lactate increase TREK1 activity which might promote efficient potassium clearance, spatial buffering and volume regulation.Current therapeutic interventions used for the early treatment of ischaemic stroke involve administration of tissue plasminogen activator (tPA, thrombolytic therapy), aspirin, dipyridamole and clopidogrel (antiplatelet therapy), and heparin, warfarin and dabigatran (anticoagulant therapy) (Mocco et al. 2007; Whitehead et al. 2007; Melani et al. 2010; Woodruff et al. 2011; Kono et al. 2014; Ozdemir et al. 2014)."

"NeuroscienceThe Journal of PhysiologyJ Physiol 594.1 (2016) pp 59-8159Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domainSwagata Ghatak, Aditi Banerjee and Sujit Kumar SikdarMolecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka 560012, IndiaKey pointsr The physiological metabolite, lactate and the two-pore domain leak potassium channel, TREK1are known neuroprotectants against cerebral ischaemia."