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Mutated HCN4 inhibits 3',5'-cyclic AMP. 1 / 1

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"To directly investigate the role of cAMP dependent regulation of hyperpolarization activated cyclic nucleotide activated (HCN) channels in SAN activity, we generated mice with heart specific and inducible expression of a human HCN4 mutation (573X) that abolishes the cAMP dependent regulation of HCN channels."

19570998

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IndraLab

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Mutated HCN4 inhibits 3',5'-cyclic AMP. 1 / 1

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