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ERK increases the amount of USP15. 2 / 2
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"overexpression of C-Raf and activation of the ERK1/2 signaling pathway cause overexpression of USP15 expression, leading to cell proliferation and migration (87).3.2 Regulation of p38, JNK by ubiquitination."
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"Comparably, pharmacological inhibition of BRAF or ERK1/2 also significantly down-regulated USP15 expressions in BRAF -mutated human thyroid cancer cells (Fig. 4b and Supplementary Fig. 3a)."
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