IndraLab

Statements

USP7 inhibits CTNNB1. 8 / 8
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"In the presence of ODM, genetic knockout or pharmacological inhibition of USP7 in C3H10T1/2 and ST2 cells increased the alkaline phosphatase staining (Fig. 5f) and mRNA expression of Alpl and β-catenin target genes (Fig. 5g), which were blocked by WNT974 (Fig. 5f, g)."
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"USP7 represses Wnt and beta-catenin signaling through stabilization of Axin, which is a part of the destruction complex that inhibits beta-catenin."
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"Upon Wnt3a treatment, knockout of Usp7 increased Wnt3a-induced accumulation of active β-catenin in C3H10T1/2 cells (Fig. 5a)."
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"Knockout Usp7 using independent gRNAs enhanced Wnt3a-induced accumulation of active β-catenin (Fig. 6a)."
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"Consistently, knockout of USP7 enhanced Wnt3a-induced accumulation of active β-catenin in HEK293T cells (Fig. 1c)."
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"USP7 inhibits Wnt and beta-catenin signaling through promoting stabilization of Axin."
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"Ectopic expression of wild-type USP7 strongly suppressed Wnt3a-induced STF reporter and β-catenin accumulation (Fig. 1h and Supplementary Fig. 1g)."
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"USP7 inhibits Wnt/beta-catenin signaling through promoting stabilization of Axin."
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