IndraLab

Statements

USP25 inhibits Ubiquitin. 9 / 9
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"Pharmacological inhibition of USP21 restores ubiquitin-mediated degradation of these substrates, triggering apoptosis in cancer cells ."
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"Overexpression of USP21 significantly reduced ubiquitin incorporation into MARK1 but has less impact on the MARK1K768A mutant (XREF_SUPPLEMENTARY)."
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"The presumed coupling of BL1 and BL2 in USP25 may slow down Ub processing, but the interaction of Gln378 with Ub in USP28 may also facilitate stabilization and more efficient cleavage compared to USP2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP21 inhibits antiviral response independent of A20 ubiquitin editing complex."
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"Moreover, overexpression of USP21 decreased the entire pool of ubiquitin chains in cells, whereas CASP2 only decreased the excessive ubiquitin chains (Extended Data Fig. 9f), indicating that the DUB-like activity of CASP2 only responds to overloaded ubiquitination."
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"Subsequently, we demonstrate for the first time that USP25 inhibits the activation of NLRP3 by removing the ubiquitin from the K243 residue of NLRP3, suggesting K243 as a new functional residue for regulating NLRP3 activity."
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"A similar result was found in another study that increasing the expression of miR-27a-3p in the placental villus tissue of patients with RM downregulated ubiquitin-specific protease 25 (USP25), which contributes to the epithelial-to-mesenchymal transition (EMT) process, thus, suppressing the migration and invasion of trophoblast cells [65]."
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"For example, it is associated with endoplasmic reticulum-associated degradation , and acute endoplasmic reticulum (ER) stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation by USP25 ."
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"Accordingly, incubation with USP21 abrogated the Ub smearing pattern, leading to the appearance of oligomeric, as well as monomeric forms of MLKL (Fig. 2f)."
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