IndraLab

Statements


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"Interestingly, the human and fly SAGA complexes possess a module that houses ubiquitin hydrolase activity mediated by the USP22 (human) and Nonstop (fly) proteins."

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"As suspected from its domain structure, USP22 is able to hydrolyze a ubiquitin linkage from histone H2B in vitro and endogenous USP22 contributes ubiquitin hydrolase activity to the hSAGA complex."