IndraLab

Statements

KMT5A methylates TP53 on lysine. 6 / 6
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"We previously found that monomethylation of p53 at lysine 382 (p53K382me1) by the protein lysine methyltransferase (PKMT) SET8 and PR-Set 7 represses p53 transactivation of target genes."
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"Indeed, histone lysine methyltransferases KMT5 (Set9), KMT3C (Smyd2), and KMT5A (Set8) methylate p53 at specific C-terminal lysines."
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"Indeed, histone lysine methyltransferases KMT5A (Set8), KMT5 (Set9), and KMT3C (Smyd2) methylate p53 at specific C-terminal lysines [27] ."
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"21 SET8 recognizes and specifically methylates p53 at the 382 lysine site (p53K382me1)."
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"C-terminal lysine residues of p53 are methylated in vivo at K370, K372, K373, and K382 by histone lysine methyl transferases, Smyd2, SET9, G9a/Glp, and Set8, respectively. xref – xref While K372 methylation by SET9 in human cells enhanced p53 transcriptional activities, the role of p53 methylation in the mouse by Set7/9 was controversial. xref – xref However, it should be pointed out that the results from mouse embryonic fibroblasts in the mouse study might be inappropriate to apply to human epithelial cells."
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"KMT5A is a methyltransferase that can methylate lysine 20 of histone 4, lysine 382 of p53, and lysines 158 and 163 of Numb ( Dhami et al., 2013 ; Milite et al., 2016 ; Shi et al., 2007 )."
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