IndraLab

Statements

USP12 activates defense response to virus. 5 / 5
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"USP12 targeted IFI16 to enhance antiviral response."
37410794
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"USP12 sustained cellular p-STAT1 levels and promoted IFN signaling and antiviral response [ 18 ]."
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"However, it is unclear whether USP12 regulates nucleic acid sensors to modulate antiviral immune responses.In this study, we demonstrated that during DNA virus infection, USP12 positively regulates the IFI16-STING-mediated antiviral response through its deubiquitinase activity."
37410794
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"Overall, these experiments suggested that USP12 targets IFI16 to enhance antiviral response."
37410794
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"Moreover, our study has shown that the USP12-associated deubiquitination of IFI16 promoted an antiviral response."
37410794