IndraLab

Statements

Doxorubicin inhibits IKBKB. 2 / 2
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"Recently, it has also been shown that doxorubicin can initiate IkappaBalpha degradation and NF-kappaB activation independent of either IKKalpha or IKKbeta using the same in vitro models."
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"Having identified that IKKalpha has a dominant role in NF-kappaB DNA binding activity, and that both IKKalpha and IKKbeta subunits are important kinases in the phosphorylation of the p65 subunit in the face of doxorubicin, the question remains whether the deletion of IKKalpha or IKKbeta would affect the overall survival of HT1080 cells treated with doxorubicin."
18644995