IndraLab

Statements

USP22 activates PI3K. 5 / 5
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"USP22 overexpression in gastric cancer cells induces the upregulation of SOS1 and activation of the RAS/ERK and PI3K/AKT pathways."
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"Western blot analysis showed that USP22 overexpression also induced activation of the RAS/ERK and PI3K/AKT pathways in SGC7901 cells and xenograft tumor tissues."
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"Previous study also showed that USP22 promotes cell cycle progression by positively regulating the PI3K and Akt pathway [XREF_BIBR]."
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"These results suggest that USP22 downregulation inhibits OS cells by suppressing the PI3K and Akt pathway."
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"To further dissect the precise mechanism by which USP22 activates the PI3K/Akt signaling pathway, coimmunoprecipitation (Co‐IP) and mass spectrometry (MS) were utilized to identify the potential direct binding partners of USP22."
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