IndraLab

Statements

USP8 activates SMO. 10 / 19
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"USP8 Promotes Smo Accumulation in Wing Imaginal Discs."
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"In addition, a gain-of-function experiment showed that the overexpression of USP8 caused an accumulation of Smo in both A- and P-compartment cells (XREF_FIG) and caused anterior expansion of ptc-lacZ in cells that received Hh (XREF_FIG)."
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"It is also possible that USP8 promotes Smo recycling to the cell surface."
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"USP8 Promotes Smo Signaling Activity."
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"Overexpression of USP8 caused an elevation of Smo in both A- and P-compartment cells but did not ectopically activate Hh target genes, such as ptc, in A-compartment cells located away from the A/P boundary (XREF_FIG)."
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"We next wished to assess whether the accumulation of Smo induced by the overexpression of USP8 or the inactivation of Shi was due to changes in the cell surface accumulation of Smo."
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"We revealed that overexpression of usp8 blocked rack1 RNAi induced Smo degradation, suggesting that Rack1 positively regulates Smo possibly through Usp8."
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"The stimulation of Hh promotes Smo deubiquitination by ubiquitin specific protease 8 (USP8), which blocks Smo endocytosis and enhances Smo cell surface accumulation XREF_BIBR XREF_BIBR."
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"These data suggest that USP8 promotes the cell surface accumulation of Smo, and that Shi mediates Smo endocytosis."
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"Finally, USP8 has been shown to increase Sonic Hedgehog (SHH) signaling by promoting SMO activity [27], even if the possible implications of this alteration have not been studied in USP8-mutated corticotrope adenoma cells to date (Figure 1)."
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