IndraLab

Statements

Sodium atom binds KCNH2. 6 / 6
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"Another study showed the interaction between hERG and Na v 1.5, even at the level of mRNA transcripts [XREF_BIBR]."
33810249
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"Here we have focused directly on the interaction between Na + o and HERG, with a view to developing a more precise biophysical understanding of the Na + o effect and thereby illuminating the Na + o -K + o interaction."
12356854
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"We studied wild-type (WT) and mutant HERG currents and used two strategic probes, intracellular Na + (Na + i) and extracellular Ba 2+ (Ba 2+ o), to define a site where Na + o interacts with HERG."
12356854
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"Our studies of the Na + o interaction with HERG began with attempts to understand the anti-Nernstian effect of K + o and suggested that K + o acts to potently relieve inhibition of outward HERG K + current by Na + o."
12356854
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"Although such effects could be consistent with a mechanism in which Na + o preferentially interacts with the HERG inactivated state, the permeability of these mutant channels to Na + limits their utility for studying inhibition of outward HERG K + current by Na + o."
12356854
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"The ability of Na + o to occupy the HERG outer pore as demonstrated in this study does not exclude the possibility that Na + o preferentially interacts with the HERG inactivated state."
12356854