IndraLab

Statements


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reach
"On the other hand, it is conceivable that in CSN6 overexpressing cancers abundant CSN6 binds more amounts of Cullin and thus reduces the accessibility of Cullin to CSN5 for deneddylation, thereby preserving Cullin neddylation."

sparser
"Indeed, based on the mole fraction of Csn6 that is bound to individual cullins, up to 60% of CSN remains associated with cullins following immunoprecipitation ( xref )."