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USP28 inhibits USP28. 3 / 3
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"Thus, complete loss of Usp28 promotes Pin1 dependent degradation of Fbw7 by the proteasome, most likely via enhanced autocatalytic ubiquitination.Destabilization of Fbw7 in Usp28 -/- cells suggested t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly to the case of NRF2, the deubiquitinases can prevent the degradation of HIF-1α so their activity must be taken into consideration when developing a possible therapy based on the increased HIF-1α ubiquitination.For example, the ubiquitination of HIF-1α mediated by FBXW7, analyzed earlier in this review, may be inhibited by the action of the Ubiquitin Specific Peptidase 28 (USP28), which acts as a FBXW7 regulator [102]."
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"However, a trend towards increased USP28 protein expression was detected in CD3/CD28 activated helper T cells at 72h compared to resting naïve T cells ( Figure 1C ), suggesting that USP28 protein levels are induced by T cell activation.To better understand the role of USP28 in T cells, USP28 knockout (USP28 ) and their littermate control mice (USP28 ) were generated as previously described (24)."
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