IndraLab

Statements

USP28 inhibits USP28. 3 / 3
| 3
reach
"However, a trend towards increased USP28 protein expression was detected in CD3/CD28 activated helper T cells at 72h compared to resting naïve T cells ( Figure 1C ), suggesting that USP28 protein levels are induced by T cell activation.To better understand the role of USP28 in T cells, USP28 knockout (USP28 ) and their littermate control mice (USP28 ) were generated as previously described (24)."
39076972
reach
"Thus, complete loss of Usp28 promotes Pin1 dependent degradation of Fbw7 by the proteasome, most likely via enhanced autocatalytic ubiquitination.Destabilization of Fbw7 in Usp28 -/- cells suggested t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25437563
reach
"Similarly to the case of NRF2, the deubiquitinases can prevent the degradation of HIF-1α so their activity must be taken into consideration when developing a possible therapy based on the increased HIF-1α ubiquitination.For example, the ubiquitination of HIF-1α mediated by FBXW7, analyzed earlier in this review, may be inhibited by the action of the Ubiquitin Specific Peptidase 28 (USP28), which acts as a FBXW7 regulator [102]."
38534381