IndraLab

Statements

USP4 binds CS. 4 / 4
| 4
sparser
"Our data showed that overexpression of USP4-WT, but not USP4-CS, promoted the EGF-dependent mTORC1 activation (Fig.  xref )."
30514904
sparser
"Our data showed that ectopical expression of wild-type USP4 (USP4-WT), but not the enzyme-dead mutant USP4-CS, in which cysteine 311 was replaced with arginine xref , abrogated TSC2/RNF152-mediated ubiquitination of Rheb (Fig.  xref and Supplementary information, Fig.  xref )."
30514904
sparser
"In addition, the ectopical expression of USP4, but not the deubiquitinase enzyme dead mutant USP4-CS, blocked the interaction between Rheb and TSC2 (Supplementary information, Fig. S xref )."
30514904
sparser
"Meanwhile, reintroducing USP4 WT, but not the enzymatic dead mutant (USP4-CS), in USP4-deficient cells rescued the mTORC1 activation (Supplementary information, Fig. S xref )."
30514904