IndraLab

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UGCG decreases the amount of IRS1. 3 / 3
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"Their experiment also showed that GCs could reduce the expression of IRS-1, which would also contribute to desensitization of the skeletal muscle tissue towards the actions of insulin."
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"60,61 GCs downregulated total IRS1 expression and also stimulated Ser307 phosphorylation, which consequently attenuated the affinity of IRS1 to IR and increased IRS1 degradation."
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"In skeletal muscle, GCs were shown to cause IR by reducing transcription of IRS1, while increasing expression of proteins that interfere with insulin action, including protein tyrosine phosphatase type 1B, leukocyte common antigen related protein (LAR) and p38MAPK."
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