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RPS6KB1-S6K phosphorylates RPS6. 10 / 11
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"The S6 protein is a component of the 40S ribosomal subunit and, as phosphorylation of the S6 protein by p70 S6K correlates with increased translation, this suggests one possible mechanism by which rap[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"P70 S6K phosphorylates the ribosomal protein S6 (RPS6), resulting in increased translation of mRNAs containing a 5 ' oligopyrimidine tract, whereas phosphorylation of 4E-BP1 by mTOR relieves inhibition on the initiation factor eIF4E, resulting in more efficient cap dependent translation."
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"Active p70 s6k phosphorylates the ribosomal S6 protein and thus regulates the translation of mRNAs that contain polypyrimidine tracks (about 20% of the total mRNA) including various components of the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"P70 S6K phosphorylates eukaryotic translation Initiation Factor-4B (eIF-4B) and S6 Ribosomal Protein (S6RP), which in turn allows translation and translational elongation."
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"Upon activation by receptor tyrosine kinases or G protein coupled receptors, AKT activates mTOR, which in turn stimulates protein translation through inhibitory phosphorylation of eukaryotic translational initiation factor eIF4E binding protein 1 (4E-BP1) that inhibits eIF4E, and activating phosphorylation of p70S6 kinase (S6K) that phosphorylates ribosomal S6 protein."
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"We note that p70 (s6k) phosphorylates the ribosomal S6 protein and stimulates translation of ribosomal proteins and translation elongation factors whose transcripts contain 5 ' oligopyramidine tracts [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"P70 S6K phosphorylates the ribosomal protein S6 (rpS6), resulting in increased translation of mRNAs containing a 5 ' olygopyrimidine tract, whereas phosphorylation of 4E-BP1 by mTOR relieves inhibition on the initiation factor eIF4E resulting in more efficient cap dependent translation XREF_BIBR."
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"P70 S6K, which phosphorylates 40 S ribosomal protein S6 in response to mitogenic stimulation, is known to be involved in cell growth regulation."
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"As mentioned above, the phosphorylation status of S6 is also commonly used as a marker of mTOR activity, and previous studies have shown that S6 is predominantly phosphorylated by p70 s6k on residues such as S235/236 and S240/244 XREF_BIBR, XREF_BIBR."
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"In control fibroblasts, this stress blocked phosphorylation of two direct mTORC1 targets, p70 S6K T389 and 4E-BP1 T37/46, as well as rpS6 S235/236, which is phosphorylated by activated p70 S6K ( Figur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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