IndraLab

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COPS6 leads to the ubiquitination of FBXW7. 6 / 6
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"On the other hand, CSN6 increased the ubiquitination of FBXW7β (Fig. 3n); therefore, FBXW7β-mediated FASN ubiquitination level can be hindered by CSN6 overexpression (Fig. 3o)."
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"Further, CSN6 KD reduced the turnover rate of FBXW7β (Supplementary Fig. 3f), and overexpressing CSN6 increased the ubiquitination of FBXW7β (Supplementary Fig. 3g)."
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"These data suggest that CSN6 increases FBXW7β ubiquitination through enhancing autoubiquitination of FBXW7β, thereby reducing the steady-state expression of FBXW7β."
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"In vitro ubiquitination assays also showed that CSN6 enhanced Fbxw7 ubiquitination and diminished Fbxw7 mediated ubiquitinations of Fbxw7 's targets, Myc and cyclin E (XREF_SUPPLEMENTARY)."
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"COP9 signalosome complex subunit 6 promotes FBXW7 autoubiquitination and proteasome-mediated degradation."
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"In vitro ubiquitination assays also showed that CSN6 enhanced Fbxw7 ubiquitination and diminished Fbxw7-mediated ubiquitinations of Fbxw7’s targets, Myc and cyclin E ( xref )."
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