IndraLab

Statements

NS-5 inhibits STAT2. 6 / 6
| 6
eidos
"In ZIKV infection , NS5 induces the degradation of STAT2 in a proteasome-dependent manner , which results in suppression of type I interferon production [ 251 ] ."
| PMC
eidos
"Finally , NS5 degrades STAT2 through a proteosoma-dependent mechanism , binding to the cellular protein ubiquitin protein ligase E3 component recognin 4 ( UBR4 ) ."
25629430
eidos
"Although UBR4 does not belong to the TRIM family , it is possible that TRIM members may also be involved in STAT2 degradation by NS5 ."
28829373
eidos
"Finally , NS5 mediates the degradation of STAT2 using the proteasome machinery ."
25629430
eidos
"Kumar et al. also confirmed that ZIKV infection inhibited type I and type III IFN signal transduction , and further showed that NS5 mediates STAT2 degradation through its MTase domain interacting with STAT2 ."
33068285
eidos
"NS5 promotes STAT2 degradation to suppress the host IFN-mediated antiviral responses [ 110 ] ."
34200500