IndraLab

Statements

TNFAIP3 inhibits RIPK3. 4 / 4
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"A20 inhibits pro-necroptotic RIPK1-RIPK3 complexes."
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"In addition , A20 integrates into the downstream necrosome and restricts RIPK3 activation to limit necroptosis ( Onizawa et al , 2015 ) ."
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"Together, our results indicated that following TNF‐induced, RelA‐responsive A20 expression in a subset of cells, A20 binds to and subsequently inhibits RIPK1‐RIPK3 complexes, thereby transiently protecting these cells from necroptosis."
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eidos
"TNF-induced expression of IkappaB attenuates NFkappaB , whereas A20 inhibits IKK and RIPK3 ."
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