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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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TNFAIP3 inhibits RIPK3. 4 / 4

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"A20 inhibits pro-necroptotic RIPK1-RIPK3 complexes."

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"In addition , A20 integrates into the downstream necrosome and restricts RIPK3 activation to limit necroptosis ( Onizawa et al , 2015 ) ."

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"Together, our results indicated that following TNF‐induced, RelA‐responsive A20 expression in a subset of cells, A20 binds to and subsequently inhibits RIPK1‐RIPK3 complexes, thereby transiently protecting these cells from necroptosis."

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"TNF-induced expression of IkappaB attenuates NFkappaB , whereas A20 inhibits IKK and RIPK3 ."

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TNFAIP3 inhibits RIPK3. 4 / 4

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