IndraLab

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"Studies of USP4 knockout mice revealed that USP4 upregulates tumor growth in an mTORC1-dependent manner."

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"Meanwhile , knockdown of USP4 led to reduced tumor size , as well as reduced expression level of p-S6 , which could be rescued by the expression of Rheb-K8R ( Fig. 7d-f ; Supplementary information , Fig. S7b ) ."