IndraLab

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USP19 activates Neoplasm Invasiveness. 9 / 9
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"Collectively, our results indicate that USP19 knockdown inhibits tumor cell invasion in vitro."
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"USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life ."
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"USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer."
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"In contrast, overexpression of USP19 increased cell invasiveness both in vitro and in vivo, further validating our findings."
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"USP19 overexpression enhances migration and invasion."
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"In our study, the cell invasion and migration induced by USP19 was correlated with MMP2 and MMP9 expression and enzyme activity."
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"In accordance with our previous results, the USP19 dependent increase in invasion is also determined by its catalytic activity and presence of the transmembrane domain."
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"Transwell assay showed that knockdown of USP19 decreased invasiveness of SGC7901 cells, whereas overexpression of USP19 enhanced GES1 cell invasion (P < 0.01; XREF_FIG and XREF_FIG, respectively)."
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"USP19 knockdown impairs invasion."
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