IndraLab

Statements

USP19 activates Neoplasm Invasiveness. 11 / 11
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"USP19 knockdown impairs invasion."
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"Collectively, our results indicate that USP19 knockdown inhibits tumor cell invasion in vitro."
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"USP19 overexpression enhances migration and invasion."
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"We demonstrated that USP19 positively regulates breast tumor cells migration and invasion in vitro, and that genetic silencing reduces cells motility, whereas its overexpression increases migratory and invasive capabilities—dependent on USP19’s catalytic activity and ER localization."
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"USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life ."
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"Transwell assay showed that knockdown of USP19 decreased invasiveness of SGC7901 cells, whereas overexpression of USP19 enhanced GES1 cell invasion (P < 0.01; XREF_FIG and XREF_FIG, respectively)."
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"In our study, the cell invasion and migration induced by USP19 was correlated with MMP2 and MMP9 expression and enzyme activity."
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"USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer."
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"In contrast, overexpression of USP19 increased cell invasiveness both in vitro and in vivo, further validating our findings."
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"In accordance with our previous results, the USP19 dependent increase in invasion is also determined by its catalytic activity and presence of the transmembrane domain."
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"These results suggest that USP19-CY promotes TGF-β-induced EMT, as well as basal and TGF-β-mediated cell migration and invasion."
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