IndraLab

Statements

HCN4 activates CFI. 3 / 3
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"The HCN4 channel is abundantly expressed in the sinoatrial (SA) node and cardiac conduction tissue, and underlies the funny current (I f)."
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"HCN4 activity underlies the funny current (I f) that governs cardiac pacemaking, and mutations in HCN4 have been associated with various forms of sinus nodal dysfunction XREF_BIBR, XREF_BIBR."
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"Based on our findings it is reasonable to speculate that ectopic atrial trigger activity (i.e. pulmonary vein sleeves) may be augmented by HCN4-P883R activating I f at more depolarized potentials."
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