IndraLab

Statements

BAP1 decreases the amount of H2Aub. 7 / 7
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"Our analysis showed that BAP1 restoration in control UMRC6 cells decreased H2Aub and SLC7A11 levels to similar degrees to that in NRF2 or ATF4 KO UMRC6 cells, suggesting that BAP1 regulates SLC7A11 expression independent of NRF2 or ATF4.PRC1 regulates SLC7A11 expression and h2aub occupancy on the SLC7A11 promoterSince our study suggested that BAP1 represses SLC7A11 expression through regulating H2Aub CELL CYCLE777Figure 1."
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"As the expression of BAP1, but not its catalytic dead form, is known to reduce the global levels of H2Aub, this strategy has been used to capture genomic locations that exhibit higher levels of H2Aub using chromatin immunoprecipitation in combination with next-generation genome sequencing (ChIP-Seq) ."
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"SLC7A11 appears to be a direct target of BAP1, which reduces the levels of H2Aub on SLC7A11 promoter, but yet represses its transcriptional activity."
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"To date, all DUBs regulating ferroptosis through the inhibition of system Xc‐/GPX, such as OTU DUB, ubiquitin aldehyde binding 1 (OTUB1), could directly interact with and stabilize SLC7A11 to inhibit ferroptosis, and BRCA1 associated protein 1 can decrease the amount of H2Aub occupying the SLC7A11 promoter to inhibit SLC7A11 expression, thereby inhibiting cystine uptake, resulting in increased levels of lipid peroxidation."
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"Our own findings suggest that BAP1 inhibition leads to increased level of H2Aub, which interferes with chromatin and histone modifications at double-strand breaks."
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"Furthermore, BAP1 was found to inhibit the expression of SLC7A11 by reducing the H2Aub level on the promoter of SLC7A11."
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"To test this hypothesis, we conducted gene set enrichment analysis (GSEA) on the genes with different fold changes in BAP1 dependent H2Aub reduction (5837 genes whose H2Aub levels were reduced by BAP1 by> 1.6-fold, 1494 genes by> 2-fold, and 101 genes by> 2.5-fold)."
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