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HgpA decreases the amount of OTUD5. 2 / 2

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"This finding identifies OTUD5 as an inhibitor of TAK1 activation, which may serve as an alternative therapeutic strategy to regulate TAK1 hyperactivation.A limitation of this study may be the unclear mechanism by which diabetes or HG/PA downregulates OTUD5 expression in podocytes."

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"The protein expression of OTUD5 was also decreased by HG/PA stimulation in a time-dependent manner in podocytes (Fig. 1d, Supplementary Fig. 1b)."

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HgpA decreases the amount of OTUD5. 2 / 2

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