IndraLab

Statements


Lipopolysaccharide decreases the amount of USP8. 3 / 3
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"Consistent with our expectation, we observed that melatonin inhibited NICD ubiquitination and restored the decreased expression of USP8 induced by LPS, thus maintaining the stability of the Notch signaling pathway."

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"We propose that LPS inhibits expression of a deubiquitylating enzyme USP8 to decrease the level of NICD."

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"LPS injection induced a time-dependent decrease in endogenous USP8 levels."