IndraLab

Statements

BRCA1 binds BAP1. 98 / 103
5 1 | 39 53
sparser
"The region of BAP1 that binds to BRCA1 spans amino acids 596–721, while the region that interacts with BARD1 is from 182 to 365 [ xref ]."
38999524
sparser
"Hence, as BAP1 protein interacts with BRCA1 protein, PARP inhibitors might also be useful in the treatment of patients with somatic BAP1 inactivation."
33866194
reach
"BRCA1 also interacts with BAP-1 (BRCA1 associated protein) [28], a member of the ubiquitin C-terminal hydrolase family, that removes ubiquitin from proteins."
11927276
reach
"XREF_BIBR It was initially suggested that BAP1 bound BRCA1 cleaves ubiquitin, and enhances the growth-suppressive effects of BRCA1."
24855403
sparser
"Thus, NUMB enhances Notch signaling by regulating the ubiquitinating activity of the BAP1–BRCA1 complex."
31504682
reach
"Importantly, artificial upregulation of BAP1 restored the protein level of BRCA1 in cells, while it had little effect on the BRCA1 mRNA expression.Following the findings above, we then focused on the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37414201
reach
"First, the interaction between BAP1 and BRCA1 in RTECs was validated by Co-IP and Western blot analysis ( Fig. 5 A)."
37414201
reach
"The interaction between BAP1 and BRCA1 and their roles in AKI were further examined in vivo ."
37414201
reach
"Therefore, we opine that the BAP1/BRCA1 interaction inactivates the NF-κB signaling to protect septic AKI.In conclusion, this study demonstrates that BAP1 protects mice from sepsis-induced AKI by deub[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37414201
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
19571111
reach
"Although BAP1 was originally identified as a protein associated with the BRCA1 tumor suppressor, the significance of the BAP1 and BRCA1 interaction has thus far remained unclear ."
37009801
sparser
"As BAP1 interacts with BRCA1, PARP inhibitors might also exhibit synthetic lethality with BAP1 mutation."
25970771
reach
"BAP1 (BRCA1 associated protein) is a member of the ubiquitin C-terminal hydrolase (UCH) family and can bind BRCA1."
19865540
sparser
"BAP1 is associated with BRCA1 but does not lead to its deubiquitylation."
28229253
sparser
"Moreover, BRCA1 interacts with the de-ubiquitinating enzyme BAP1 ( Fig. 1 ) [43] ."
16337408
sparser
"We have shown that BAP1 binds to the RING finger domain of BRCA1, but not to BRCA1 RING finger domains containing mutations identified from breast cancer kindreds or to other related RING finger do[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10546591
sparser
"These data reveal that the interaction between BAP1 and BRCA1 is specific (BAP1 does not bind to any other RING finger domain tested to date) and suggests that the absence of BAP1 binding to mutat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10546591
sparser
"There are four of these in the human genome and one of these is BAP1 which binds the BRCA1 breast cancer susceptibility gene and can function as a tumor suppressor ( Jensen et al., 1998 )."
23680672
sparser
"Subsequent studies suggested that BAP1 may not bind directly to BRCA1 but to BARD1 instead, thereby indirectly influencing BRCA1 activity through disruption of the BRCA1–BARD1 complex, thus downmodulating the E3 ligase function of BRCA1 ( xref )."
32690542
sparser
"Furthermore, we found that all three mutant BAP1 forms increased BRCA1 protein levels (Fig. xref )."
26011428
reach
"Moreover, BRCA1 interacts with the de-ubiquitinating enzyme BAP1 [43]."
16337408
reach
"BAP1 direct physical interaction with BRCA1-RING finger domain was associated to enhancement of BRCA1 tumour suppressor activity in breast cancer [11] (Fig. 1a)."
36318367
sparser
"The DUB BAP1 associates with BRCA1, and is mutated in a number of cancers, particularly mesothelioma and melanoma."
28587922
reach
"BAP1 is involved in multiple processes, including DDR, and acts as a TSG by binding to BRCA1, another well-known TSG.29 BAP1 is located on chromosome 3p21, which is often lost in various malignancies."
37453150
sparser
"Jensen et al. showed that BAP1 can interact with BRCA1 and augment the tumor suppressor activity of BRCA1 ( xref )."
35875073
sparser
"This is because BAP1 interacts with BRCA1, and BAP1 mutation likely alters the HR DNA repair pathway."
35463363
sparser
"Although the direct interaction of BAP1 with BRCA1 remains controversial [ xref ], several studies report a potential role of BAP1 in DNA damage repair, and particularly in homologous recombination (HR)."
31146482
sparser
"Several studies and clinical trials [ xref ], have shown that PARP inhibitors influence cancers in which mutations in BRCA1 or BRCA2 are observed, which led us to assume that the cancerous growth-inhibiting interaction of BAP1 with BRCA1 may already be perturbed in this case, and that PARP inhibitors may actually be blocking the novel interaction of BAP1 with PARP3 which enhances cancer growth."
33916178
reach
"χ 2 test or Fisher's exact test (in case of low event rates [n<5]) were used to investigate the association between BRCA1 and BAP1, p16ink4A, and PD-L1 expression and response outcome."
35157829
sparser
"Due to the association of BAP1 with BRCA1, it was hypothesized that BAP1-mutated PM might show synthetic lethality with PARP inhibition, but PM cell lines with wild-type and mutated BAP1 showed simila[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37730104
biogrid
No evidence text available
37655321
reach
"However, it is possible that BAP1 interacts with BRCA1 under a particular set of circumstances, such as in response to DNA damage."
23867514
sparser
"However, it is possible that BAP1 interacts with BRCA1 under a particular set of circumstances, such as in response to DNA damage."
23867514
sparser
"This result suggests that BAP1 contributes to the stabilization of BRCA1 and that the COOH-terminal side of BAP1, even with a small mutation inside, may confer the stability of the BRCA1 protein, probably through the BAP1–BRCA1 interaction."
26011428
reach
"Binding of BAP1 to the BRCA1-BARD complex interferes with BRCA1 E3 ligase activity and leads to S-phase arrest and increased susceptibility to DNA damage."
40061651
sparser
"We went on to determine whether NUMB acts as the adaptor to facilitate BAP1–BRCA1 role in stabilizing N1ICD."
31504682
sparser
"Interaction of BAP1 with BRCA1 has been shown to inhibit breast cancer growth [ xref ]."
33916178
sparser
"7 It was initially believed that BAP1 bound to BRCA1, cleaved ubiquitin and enhanced the growth suppressive effects of BRCA1.1,28 Subsequent studies cast some doubt on the role played by BAP1 in the B[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23277170
sparser
"For example, the deubiquitinase BAP1 interacts with BRCA1, an E3 ligase frequently mutated in breast cancer."
21111230
biogrid
No evidence text available
9528852
biogrid
No evidence text available
9528852
biogrid
No evidence text available
9528852
biogrid
No evidence text available
9528852
sparser
"BAP1 direct physical interaction with BRCA1-RING finger domain was associated to enhancement of BRCA1 tumour suppressor activity in breast cancer [ xref ] (Fig.  xref a)."
36318367
sparser
"BAP1-BRCA1 interaction is however still controversial [ xref ]."
36318367
sparser
"32 Deletion of the BRCA1-binding domain abolishes the BAP1–BRCA1 interaction."
26876698
hprd
No evidence text available
9528852
sparser
"Multiple studies found that patients harboring a functional somatic mutation in the BAP1 gene that binds to the BRCA1 and acts as a tumor suppressor gene did not respond well to everolimus and sunitinib treatments as compared to patients with wild-type BAP1 ( xref , xref )."
35775004
sparser
"In mediating DNA damage response, BAP1 interacts with BRCA1 ( xref , xref )."
33330039
sparser
"As BAP1 interacts with BRCA1, several lines of evidence indicate that alterations in the BRCA-mediated DNA repair pathway confers sensitivity to PARP inhibitor administration ( xref )."
33330039
reach
"One of these is BAP1 which binds the BRCA1 ubiquitin ligase and functions as a tumor suppressor ( Ventii et al., 2008 )."
27475983
reach
"The RING from Rpt1, which has more than 90 % sequence identity with the RING of BRCA1, cannot support binding of BAP1 when substituted for BRCA1’s domain (Jensen et al ., 1998) ."
10653689
sparser
"Although several functional interactions have been described for these two proteins [ xref , xref ], it is still controversial whether BAP1 and BRCA1 (the latter being a tumor suppressor gene with a ubiquitin E3 ligase activity) physically interact with each other."
36980270
sparser
"Interestingly, BRCA1 also interacts with BAP1, a ubiquitin hydrolase [ xref ]."
11879553
sparser
"The mechanism of BRCA1 loss is unknown, and 2) the potential functional interaction between BRCA1 and BAP1 linked to spindle checkpoint is unknown."
30405205
reach
"Myotubularin related protein 3 (MTMR3) induces the expression of p27; BRCA1 associated protein-1 (BAP1) interacts with BRCA1 and suppresses cancer cell growth; sphingosine-1-phosphate lyase 1 (SGPL1) may play a role in cancer-surveillance pathways; aryl-hydrocarbon receptor repressor (AHRR) is an angiogenic factor; and sialidase 1 (lysosomal sialidase) (NEU1) inhibits tumor metastasis by decreasing integrin beta4 signaling and down-regulating MMP-7."
20886540
reach
"In mediating DNA damage response, BAP1 interacts with BRCA1."
33330039
sparser
"One possibility is that BRCA1 and BAP1 interact specifically in the setting of DNA damage repair, where H2A is monoubiquitinated by BMI1, and BRCA1 is recruited to DNA lesions [ xref , xref ]."
23915344
sparser
"The BAP1 region that interacts with BRCA1 is located between amino acids 596 and 721, while the region that interacts with BARD1 is from 182 to 365."
26166446
sparser
"Out of these genes, BRCA1-BAP1 (breast cancer gene 1-associated protein 1) is the most common in PM (approximately 60%) [ xref , xref , xref ]."
39329996
reach
"The mechanism of BRCA1 loss is unknown, and 2) the potential functional interaction between BRCA1 and BAP1 linked to spindle checkpoint is unknown."
30405205
reach
"Interestingly, BRCA1 also interacts with BAP1, a ubiquitin hydrolase [XREF_BIBR]."
11879553
reach
"As BAP1 interacts with BRCA1, PARP inhibitors might also exhibit synthetic lethality with BAP1 mutation."
25970771
reach
"BAP1 mediated tumour suppression is achieved through the cell cycle by accelerating progression through the G1-S checkpoint, leading to an accumulation of DNA damage and cell death.4 BAP1 depleted cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23277170
reach
"BAP1 interacts with BARD1 (182aeuro " 365), HCF-1 (365aeuro " 385), BRCA1 (596aeuro " 721) and YY1 (642- 686).10,88 Numbers refer to amino acid positions."
23277170
sparser
"This suggests that the effects of BAP1 on foci assembly could involve direct histone H2A-deubiquitination, although other mechanisms, for example involving the interaction of BAP1 with BRCA1 ( Jensen [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
sparser
"xref a illustrates the difficulty of curating a publication describing interactions between a well-known breast cancer protein BRCA1 and another protein, BAP1, which binds to BRCA1 and enhances cell-growth suppression ( xref )."
21183497
sparser
"The published text describes the interactions between the BRCA1 RING finger domain (which has the same sequence in human and mouse) with the human BAP1 protein as well as with different variants of the BAP1 mouse ortholog."
21183497
reach
"The molecular pathways of BAP1 in carcinogenesis are not well understood, and it was previously suggested that BAP1 interacted with BRCA-1; however, recent evidence has contradicted this theory [XREF_BIBR]."
29085180
reach
"To investigate the alteration of BAP1 induced by PT33 and the formation of HERC2–BAP1–BRCA1 complex, more work is required to conduct in the future.5 Conclusions."
37655321
sparser
"Several lines of evidences indicate that PARP inhibitor administration might be an effective treatment in presence of BAP1 and/or RAD21 alterations since both BAP1 and RAD21 are involved in the DNA repair pathway, BAP1 interacts with BRCA1 and BRCA1-mediated DNA repair pathway alterations enhance the sensitivity to PARP inhibitor administration."
33330039
sparser
"Because of the involvement of RAD21 in the DNA repair pathway, the interaction of BAP1 with BRCA1 and the enhanced sensitivity to PARP inhibitor administration in presence of alterations in the BRCA1-mediated DNA repair pathway, it was decided first to treat the patient with FOLFIRI every 2 weeks [irinotecan 180 mg/m 2 , folinic acid 400 mg/m 2 , 5-fluorouracil (5-FU) 400 mg/m 2 intravenous infusion bolus, then 5-FU 2400 mg/m 2 intravenous infusion over 46 h] and then to start a PARP inhibitor."
33330039
reach
"31,32 Because BAP1 can interact with BRCA1 and because BAP1FL reconstitution in BAP1-null cell lines leads to resistance to PARP inhibition (unlike in BAP1Delta reconstituted cells), we analyzed the e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28389374
reach
"Several lines of evidences indicate that PARP inhibitor administration might be an effective treatment in presence of BAP1 and/or RAD21 alterations since both BAP1 and RAD21 are involved in the DNA repair pathway, BAP1 interacts with BRCA1 and BRCA1 mediated DNA repair pathway alterations enhance the sensitivity to PARP inhibitor administration."
33330039
reach
"BAP1 (BRCA1 Associated Protein 1), a ubiquitin hydrolase that binds to BRCA1 (Breast Cancer susceptibility 1) and is recruited to sites of DNA double-strand breaks for repair, is shown to be inactivated in ~ 65% of MM [11-13]."
32183600
reach
"As BAP1 interacts with BRCA1, several lines of evidence indicate that alterations in the BRCA mediated DNA repair pathway confers sensitivity to PARP inhibitor administration."
33330039
sparser
"Although BAP1 was originally identified as a protein associated with the BRCA1 tumor suppressor, the significance of the BAP1 and BRCA1 interaction has thus far remained unclear xref – xref ."
37009801
reach
"(1999) S13-S17 Defining biochemical functions for the BRCA1 tumor suppressor protein : analysis of the BRCA1 binding protein BAP1 David E. Jensen, Frank J. Rauscher III * The Wistar Institute, 3601 Sp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10546591
reach
"These data reveal that the interaction between BAP1 and BRCA1 is specific (BAP1 does not bind to any other RING finger domain tested to date) and suggests that the absence of BAP1 binding to mutated B[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10546591
sparser
"Following the findings above, we then focused on the interaction between BAP1 and BRCA1 and their roles in sepsis."
37414201
sparser
"The interaction between BAP1 and BRCA1 and their roles in AKI were further examined in vivo ."
37414201
sparser
"31,32 Because BAP1 can interact with BRCA1 and because BAP1FL reconstitution in BAP1-null cell lines leads to resistance to PARP inhibition (unlike in BAP1Δ-reconstituted ce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28389374
sparser
"Interestingly, a recently identified protein, BAP1 which contains a UCH domain, binds BRCA1 (a transcriptional regulator) RING finger domain and enhances BRCA1-mediated cell growth suppression [17] ."
11163772
reach
"Although the molecular genetics of cutaneous melanomas have been investigated in numerous studies [XREF_BIBR, XREF_BIBR, XREF_BIBR], the genetic events that lead to the development of CBN, MABN or ACBN are poorly understood and are limited to a few genes [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR], including BAP1 (BRCA1 binding protein 1), an oncogenic deubiquitinase, which has been found to be mutated in metastatic uveal melanomas and MABNs [XREF_BIBR]."
27057633
reach
"The DUB BAP1 associates with BRCA1, and is mutated in a number of cancers, particularly mesothelioma and melanoma."
28587922
reach
"Multiple studies found that patients harboring a functional somatic mutation in the BAP1 gene that binds to the BRCA1 and acts as a tumor suppressor gene did not respond well to everolimus and sunitinib treatments as compared to patients with wild-type BAP1 (80, 81)."
35775004
reach
"Defining biochemical functions for the BRCA1 tumor suppressor protein : analysis of the BRCA1 binding protein BAP1."
10546591
sparser
"The molecular pathways of BAP1 in carcinogenesis are not well understood, and it was previously suggested that BAP1 interacted with BRCA-1; however, recent evidence has contradicted this theory [ xref ]."
29085180
reach
"The region of BAP1 that binds to BRCA1 spans amino acids 596–721, while the region that interacts with BARD1 is from 182 to 365 [1]."
38999524
sparser
"BAP1 belongs to a subfamily member of deubiquitinating enzymes and is a novel ubiquitin carboxy-terminal hydrolase.[ xref , xref ]BAP1 can bind to BRCA1 in the nucleus and increase BRCA1 tumor suppressor activity.[ xref ]It was reported that BAP1-related ceRNA (NEAT1/miR-10a-5p/SERPINE1) promotes kidney cancer cell proliferation and migration.[ xref ]SETD2 is a histone H3 lysine 36 (H3K36) trimethyltransferase and is one of the frequently mutated genes in ccRCC.[ xref ]SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes.[ xref ]"
39470474
sparser
"This domain is also required for mediating BAP1 interaction with BRCA1 ."
26300492
sparser
"The predicted interaction domain between BAP1 and HTT spans aa 528–669 of BAP1, partially overlapping with a coiled-coil domain and the BAP1–BRCA1 interaction domain ( xref )."
39705313
sparser
"BARD1 appeared to be a possible candidate because although BAP1 stands for “BRCA1-associated-protein-1” ( xref ) a subsequent study proposed that BAP1 does not bind BRCA1, rather it binds BARD1 preventing its binding to BRCA1 ( xref )."
38990952
reach
"Further credence was given to the physiological relevance of the BRCA1 and BAP1 interaction by our data which show that BAP1 mRNA is expressed in tissues which also express BRCA1 mRNA, and that the sp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10546591
sparser
"Taken together, we hypothesized that BAP1 interacts with BRCA1 protein to regulate the inflammation and organ injury through the NF-κB signaling pathway."
37414201
reach
"Interestingly, though the BAP1 protein associates with BRCA1, the data to support melanoma predisposition in carriers of either BRCA1 or BRCA 2 is mixed."
34638397
sparser
"BAP1 binds to the wild-type BRCA1 RING finger domain, but not to mutated RING fingers or other closely related RING fingers [11] ."
20302916
reach
"Due to the interaction between BAP 1 and BRCA1, studies are now investigating for the potential to treat with PARP inhibitors, with The Mesothelioma Stratified Therapy (MiST) nonrandomized phase II trial showing that PARP inhibition with rucaparib in refractory malignant mesothelioma of any type resulted in 58% disease control at 12 weeks, 23% at 24 weeks, and was well tolerated [88•]."
35657483