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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Hydrogen-Ion Concentration leads to the deubiquitination of USP28. 2 / 2

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"Chronic stress induced epinephrine activated LDHA to generate lactate, and the adjusted pH directed USP28 mediated deubiquitination and stabilization of MYC."

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"This leads to a switch to lactate production, and the adjusted pH then directs USP28 mediated deubiquitination and stabilization of MYC, thereby promoting stem like traits in breast cancer."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...