IndraLab

Statements

USP47 activates EZH2. 2 / 2
| 2
reach
"USP47 inhibition blocked the function of mutated EZH2 through ubiquitination and EZH2 degradation, increasing the sensitivity of diffuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML) cells to EZH2 inhibitors, such as the recently FDA-approved EPZ-6438, in vitro and in vivo ."
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reach
"The inhibition of USP47 by a small molecule was efficient in degrading EZH2 in the preclinical setting, thus contributing to potential EZH2-targeted therapeutics [ 62 ]."
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