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Mutated BAP1 inhibits signal transduction. 5 / 5
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"These previous studies can support our finding that BAP1 mutations causing loss of BAP1 expression could induce the immunosuppressive microenvironment in UM.Mechanistically, we demonstrated in the current study that BAP1 mutations could inhibit the NF-κB signaling pathway, thereby repressing the cytokine secretion and antigen presentation by macrophages and inducing immunosuppressive microenvironment in UM."
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"A preliminary conclusion can be drawn in the current study that BAP1 mutations might repress the NF-κB signaling pathway, which repressed the cytokine secretion and antigen presentation by macrophages, inducing the immunosuppressive microenvironment, augmenting the malignant phenotypes of UM cells and ultimately promoting the growth and metastasis of UM (Fig. 10)."
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"BAP1 mutations inhibit the NF-kappaB signaling pathway to induce an immunosuppressive microenvironment in uveal melanoma."
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"BAP1 mutations inhibited the NF-kappaB signaling pathway, suppressing the cytokine secretion and antigen presentation by macrophages."
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"BAP1 mutations may inhibit the NF-kappaB signaling pathway, repressing the cytokine secretion and antigen presentation by macrophages, which induces the immunosuppressive microenvironment, enhances the malignant phenotypes of UM cells and ultimately promotes the growth and metastasis of UM."
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