IndraLab

Statements

E3_Ub_ligase binds KCNH2. 2 / 2
| 1 1
sparser
"Ablation of the neural precursor cell–expressed developmentally down-regulated protein 4 long isoform (Nedd4-2) E3 ligase, which associates with the C-terminal PY motif of hERG ( xref ), failed to counteract the metabolic instability in the presence of glycosides or hERG mutations (Supplemental Figure S5, C and F, and unpublished data)."
24152733
reach
"For instance, the E3 ligase Nedd4-2 (Rsp5 in yeast) binds the PPxY motif in Kv11.1, which leads to monoubiquitination, channel internalization, and degradation [198–200]."
36638864