IndraLab

Statements

BAP1 binds FOXO3. 16 / 16
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"Both endogenous and exogenous CoIP demonstrated that BAP1 protein could directly bind to FOXO3a protein in cells."
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"Moreover, the binding of the transcription factor FOXO3a with the BAP1 promoter can modulate neuronal lipid peroxidation and ferroptosis by enhancing BAP1 expression."
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"Consequently, the FOXO3a-BAP1 axis might represent a promising therapeutic strategy for addressing neuronal ferroptosis in patients with SAH."
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"Our findings elucidate the impact of FOXO3a and BAP1 on SLC7A11-related ferroptosis following SAH both in vivo and in vitro , and the inhibition of the FOXO3a-BAP1 axis can significantly attenuate neuronal damage and ferroptosis in EBI after SAH."
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"Preliminary experiments have revealed that FOXO3a can bind to the BAP1 promoter and regulate the expression of BAP1."
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"Consequently, this study aimed to investigate the potential mechanism by which FOXO3a-BAP1 influences neuronal ferroptosis in the pathogenesis of EBI after SAH."
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"BAP1 directly interacted with FOXO3a."
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"To explore whether DUB BAP1 directly regulates the above proteins through deubiquitination in neurons after SAH, the binding of BAP1 with FOXO3a proteins was detected by prediction of protein-protein interactions and CoIP assay."
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"Endogenous CoIP also revealed that BAP1 protein could directly bind to FOXO3a protein in HT22 cells ( xref B)."
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"To explore whether DUB BAP1 directly regulates the above proteins through deubiquitination in neurons after SAH, the binding of BAP1 with FOXO3a proteins was detected by prediction of protein-protein interactions and CoIP assay."
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"To further study the interaction between FOXO3a and BAP1, 293T cells were transfected with Flag-FOXO3a and HA-BAP1 for 48h, and control cells were transfected with empty plasmid with Flag or HA label respectively."
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"Moreover, the binding of the transcription factor FOXO3a with the BAP1 promoter can modulate neuronal lipid peroxidation and ferroptosis by enhancing BAP1 expression."
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"These results suggested that the endogenous deubiquitination enzyme BAP1 can directly bind to the FOXO3a protein in neuron."
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"The ChIP experiment demonstrated that FOXO3a could bind to the promoter region of BAP1, thereby regulating its mRNA expression levels."
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"Moreover, CoIP experiments revealed that the deubiquitination enzyme BAP1 directly interacts with FOXO3a through the UCH domain and mediates the deubiquitination of FOXO3a protein."
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"These results also suggest that the FOXO3a-BAP1 axis can enhance ferroptosis in neurons after SAH through transcriptome regulation and deubiquitination modification."
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