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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

HSP90beta increases the amount of KCNQ4. 2 / 2

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"In a recent analysis of chaperones, knockdown and overexpression showed that HSP90beta, HSC70 and DNAJA1 enhance KCNQ4 levels, consistent with increased folding; however, HSP90alpha diminished KCNQ4 levels (XREF_TABLE)."

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"KCNQ4 surface expression was restored by HSP90beta in cells mimicking heterozygous conditions of the DFNA2 patients, even though it was not sufficient to rescue the function of KCNQ4 channels."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...