IndraLab

Statements

ECT2 leads to the deubiquitination of USP7. 5 / 5
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"Consistent with the results from in vivo deubiquitination assay, in vitro deubiquitination assay with Sf9 cells purified USP7 and His Ub conjugated USP7 and C223S purified from HeLa cells by high salt and denature buffer demonstrated that ECT2 addition markedly promoted USP7 self deubiquitination."
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"ECT2 antagonizes USP7 polyubiquitination and promotes its stabilization."
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"To test whether ECT2 promoted USP7 stabilization is through opposing ubiquitination mediated proteasome degradation, we next examined whether ECT2 functions to antagonize USP7 ubiquitination."
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"Surprisingly, we uncovered that ECT2 promotes intermolecular self association and self deubiquitination of USP7."
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"Furthermore, we revealed that ECT2 and GEF mt promotes USP7 deubiquitination as efficiently as ECT2/wt does."
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