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OTUD5 activates HNF1A. 3 / 3
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"In the present study, we discovered that overexpression of OTUD5 promoted HNF1α/HNF4α protein and mRNA expression while down-expression of OTUD5 inhibited HNF1α/HNF4α protein and mRNA expression in hepG2 2.15 cells (Fig. 6A–E)."
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"The data of PCR showed that knockdown of OTUD5 significantly downregulated the mRNA of HNF1ɑ and HNF4ɑ (Fig. 6B,C)."
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"Conversely, the overexpression of OTUD5 could upregulate the mRNA of HNF1ɑ and HNF4ɑ (Fig. 6E–F)."
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