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KCNQ1 activates potassium(1+). 25 / 25
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"Previous studies have shown that genetic deletion of either the pore forming, KCNQ1, or regulatory, KCNE1, subunit of the large conductance, Ca 2+ - and voltage activated potassium (BK) channel produces hyperaldosteronism in mice XREF_BIBR, XREF_BIBR."
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"The present study was designed to investigate the functional significance of KCNQ1 mediated K+ secretory fluxes in proximal tubular cells of the frog kidney."
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"The present study explored the influence of KCNQ1 on insulin induced cellular K+ uptake and glucose metabolism."
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"By contrast, heterologous expression of KVLQT1 and minK together led to a large potassium current with the biophysical properties of cardiac I Ks."
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"This process also requires a constitutive active potassium channel consisting of the KCNQ1 and KCNE2 subunits promoting potassium efflux [XREF_BIBR - XREF_BIBR]."
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"The slowly activated delayed rectifier potassium current (I Ks ) mediated by the KCNQ1 gene is one of the main currents involved in repolarization."
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"There is no enhancement of the potassium currents mediated by the KCNQ1 channel subunit, which is found primarily in cardiac tissue XREF_BIBR and also in the gastrointestinal system and brain."
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"KCNE1, also known as MinK, is one of the five members of the KCNE family that modulate the voltage gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents [XREF_BIBR, XREF_BIBR]."
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"Kcnq1 contributes to an adrenergic sensitive steady-state K+ current in mouse heart."
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"In conclusion, KCNQ1 coassembles with KCNE2 to form acid activated luminal K+ channels of parietal cells."
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"Expression of KvLQT1 subunits produces small, rapidly activating potassium currents; coexpression of these with minK results in slowly activating I Ks currents that are several-fold larger."
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"Kcne1, Kcnq1, and Kcnq4 encode subunits of inward rectifier voltage activated potassium channels."
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"Phosphorylation of KCNQ1 is crucial for slow activating delayed potassium current (I Ks)."
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"KCNE1 is known to modulate the voltage gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents."
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"In concert with K V 7.4 in outer hair cells, K V 7.1 (KCNQ1) in the stria vascularis, calcium activated potassium channels BK (KCNMA1) and SK2 (KCNN2) in hair cells and efferent fiber synapses, and K V 3.1 (KCNC1) in the spiral ganglia and ascending auditory circuits share an upregulated expression or subcellular targeting during final differentiation at hearing onset."
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"KvLQT1 gene product is associated with the regulator protein IsK to produce a component of the delayed rectifier K+ current in cardiac myocytes."
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"The coassembly of KCNQ1 and KCNE1 produces the I KS potassium current that is critical for the late repolarization of the cardiac action potential."
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"14 While the current study can not improve upon the numerical KCNQ1 " threshold " required for hearing preservation, it is clear from this study and others that the complete cessation of KCNQ1 mediated K+ secretion in the inner ear linked to the bi-allelic inheritance of two truncating and haploinsufficient mutations is the primary mechanism that disrupts cochlear fluid homeostasis resulting in the collapse of endolymphatic compartment and sensorineural deafness in JLNS patients and murine JLNS models."
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"KCNQ1 contributes to a potassium current that terminates the cardiac action potential."
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"Coexpression of KvLQT1 in association with the channel regulator protein IsK produces a K+ current with characteristics reminiscent of the slow component of the delayed rectifier in cardiac myocytes."
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"In addition to I to, f and I Kur, human atrial myocytes also exhibit a rapidly activating and inactivating current (I Kr) and a slowly activating current (I Ks), mediated by hERG1 and KCNQ1 channels, respectively, but they are much smaller outward potassium currents relative to I to, f and I Kur [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"KCNQ1 and minK channels probably mediate the secretion of potassium into the endolymph that bathes the apical surface of the hair cells that convert mechanical stimulation into electrical signals."
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"Gastric acid secretion can be strongly inhibited by application of the KCNQ1 blocker chromanol 293B, thereby inhibiting potassium efflux and maintaining a hyperpolarized parietal cell by way of intracellular potassium accumulation."
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"Expression of both human and rat KCNQ1 induced time dependent K+ currents that were sensitive to Ba2+ and 293B."
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"As seen in Fig. 1 a, a similar biphasicity is also present in a high Na + solution, where the tail currents are in the outward direction, supporting the idea that it is a distinguishing feature of the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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