IndraLab

Statements

KCNQ1 activates potassium(1+). 37 / 37
| 37
reach
"The slowly activated delayed rectifier potassium current (I Ks ) mediated by the KCNQ1 gene is one of the main currents involved in repolarization."
35765105
reach
"As seen in Fig. 1 a, a similar biphasicity is also present in a high Na + solution, where the tail currents are in the outward direction, supporting the idea that it is a distinguishing feature of the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9675180
reach
"Phosphorylation of KCNQ1 is crucial for slow activating delayed potassium current (I Ks)."
29370121
reach
"In conclusion, KCNQ1 coassembles with KCNE2 to form acid activated luminal K+ channels of parietal cells."
15579540
reach
"Coexpression of KvLQT1 in association with the channel regulator protein IsK produces a K+ current with characteristics reminiscent of the slow component of the delayed rectifier in cardiac myocytes."
9396783
reach
"Results indicated that wild-type KCNQ1 exhibited relatively slowly activating and deactivating potassium currents in EGFP-positive cells under voltage clamp, but the cells with the P441L channel exhibited very small rapid activation currents (Figures 3A,B)."
36386331
reach
"KvLQT1 gene product is associated with the regulator protein IsK to produce a component of the delayed rectifier K+ current in cardiac myocytes."
9506986
reach
"There is no enhancement of the potassium currents mediated by the KCNQ1 channel subunit, which is found primarily in cardiac tissue XREF_BIBR and also in the gastrointestinal system and brain."
22888276
reach
"In addition to I to, f and I Kur, human atrial myocytes also exhibit a rapidly activating and inactivating current (I Kr) and a slowly activating current (I Ks), mediated by hERG1 and KCNQ1 channels, respectively, but they are much smaller outward potassium currents relative to I to, f and I Kur [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26162324
reach
"Since the magnitude of the voltage gated current varies markedly among different oocyte batches, the current was normalized for statistical analysis as detailed in the Figure legends.ResultsThe heteromeric KCNE1 and KCNQ1 channel mediates an outwardly directed K+ current activated by depolarization of the cell membrane."
22583083
reach
"Kv7.1 is predominantly located in the basolateral membrane of these cells, facing the bloodstream, and mediates potassium efflux from cells into the circulation, which helps return the membrane potential to the resting state following an AP."
38027512
reach
"Kcnq1 contributes to an adrenergic sensitive steady-state K+ current in mouse heart."
17597584
reach
"The most frequently observed forms of congenital LQTS arise from mutations to KCNQ1 and hERG (alternative nomenclature KCNH2), which respectively contribute to the slow delayed rectifier potassium current (I , LQT1) and the rapid delayed rectifier potassium current (I , LQT2); these account for 44% and 35% of cases, respectively [9]."
38106919
reach
"The coassembly of KCNQ1 and KCNE1 produces the I KS potassium current that is critical for the late repolarization of the cardiac action potential."
15226366
reach
"Previous studies using iPSC-derived cardiomyocytes from type-1 LQTS patients revealed that the mutation in KCNQ1 caused potassium ion channel dysfunction resulting in sarcolemmal deficiency [5,6]."
35681550
reach
"Expression of both human and rat KCNQ1 induced time dependent K+ currents that were sensitive to Ba2+ and 293B."
11426298
reach
"14 While the current study can not improve upon the numerical KCNQ1 " threshold " required for hearing preservation, it is clear from this study and others that the complete cessation of KCNQ1 mediated K+ secretion in the inner ear linked to the bi-allelic inheritance of two truncating and haploinsufficient mutations is the primary mechanism that disrupts cochlear fluid homeostasis resulting in the collapse of endolymphatic compartment and sensorineural deafness in JLNS patients and murine JLNS models."
23392653
reach
"Kcne1, Kcnq1, and Kcnq4 encode subunits of inward rectifier voltage activated potassium channels."
23044516
reach
"Gastric acid secretion can be strongly inhibited by application of the KCNQ1 blocker chromanol 293B, thereby inhibiting potassium efflux and maintaining a hyperpolarized parietal cell by way of intracellular potassium accumulation."
27098917
reach
"This process also requires a constitutive active potassium channel consisting of the KCNQ1 and KCNE2 subunits promoting potassium efflux [XREF_BIBR - XREF_BIBR]."
25009573
reach
"In LQT1, the loss-of-function mutation in KCNQ1 affects the slowly activating delayed rectifier potassium current (IKs current), preventing the corrected QT interval from appropriately shortening during exercise, aiding in the diagnosis."
39027806
reach
"KCNQ1 and minK channels probably mediate the secretion of potassium into the endolymph that bathes the apical surface of the hair cells that convert mechanical stimulation into electrical signals."
10025409
reach
"KCNQ1 contributes to a potassium current that terminates the cardiac action potential."
30461122
reach
"By controlling the efflux of potassium ions, the opening of KCNQ1 channels prolongs the duration of action potentials, thus influencing muscle contraction and relaxation processes [ 50 ]."
38110106
reach
"It is reported that using iPSC cardiomyocytes from LQTS patients revealed that a mutation in KCNQ1 causes dysfunction in the potassium ion channel, resulting in a deficiency in the sarcolemma."
38963728
reach
"Kv4.3 and Kv7.1 contribute to the fast transient outward potassium current (I ) and delayed rectifier potassium current (I ) in cardiomyocytes, respectively [30]."
40334257
reach
"KCNQ1, SCN5A, SCN8A, and SCN10A mutations can also cause sudden cardiac death by disrupting potassium or sodium channel activities (48–50)."
38370698
reach
"On the other hand, as I discussed in this short review, the KCNQ1 channel goes back and forth among many states to produce a voltage-dependent (or independent) potassium current with KCNE proteins."
31236320
reach
"Previous studies have shown that genetic deletion of either the pore forming, KCNQ1, or regulatory, KCNE1, subunit of the large conductance, Ca 2+ - and voltage activated potassium (BK) channel produces hyperaldosteronism in mice XREF_BIBR, XREF_BIBR."
27432863
reach
"As acid secretion requires KCNQ1-mediated potassium recycling in parietal cells (57), the gastroprotective effect of menthol may result from the inhibition of KCNQ1.Sex differences in thermal sensitivity are well documented, and in humans and mice, females prefer warmer conditions compared to males (19–21)."
38857404
reach
"By contrast, heterologous expression of KVLQT1 and minK together led to a large potassium current with the biophysical properties of cardiac I Ks."
11239413
reach
"The present study was designed to investigate the functional significance of KCNQ1 mediated K+ secretory fluxes in proximal tubular cells of the frog kidney."
17869561
reach
"KCNE1 is known to modulate the voltage gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents."
28233402
reach
"In concert with K V 7.4 in outer hair cells, K V 7.1 (KCNQ1) in the stria vascularis, calcium activated potassium channels BK (KCNMA1) and SK2 (KCNN2) in hair cells and efferent fiber synapses, and K V 3.1 (KCNC1) in the spiral ganglia and ascending auditory circuits share an upregulated expression or subcellular targeting during final differentiation at hearing onset."
33336302
reach
"Expression of KvLQT1 subunits produces small, rapidly activating potassium currents; coexpression of these with minK results in slowly activating I Ks currents that are several-fold larger."
9834139
reach
"KCNE1, also known as MinK, is one of the five members of the KCNE family that modulate the voltage gated potassium channel alpha subunit KCNQ1 to generate slowly activating potassium currents [XREF_BIBR, XREF_BIBR]."
28233402
reach
"The present study explored the influence of KCNQ1 on insulin induced cellular K+ uptake and glucose metabolism."
19369585