IndraLab

Statements

USP2 activates TP53. 6 / 6
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"These data demonstrate that CD8 + T cells, but not CD4 + T cells, are the primary effector cells underlying the combination treatment in these tumor models.Finally, to ascertain whether USP2 inhibition potentiates the efficacy of PD-1/PD-L1 blockade by enhancing p53 function in a tumor cell autonomous manner, we also examined the effects of combination therapy in Balb/c mice bearing p53-null EMT6 tumors."
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"On the other hand , USP2 has also been shown to increase p53 in a hepatoma cell line ( HepG2 ) and a breast cancer cell line ( MCF7 ) after leptin stimulation [ 36 ] ."
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"We speculate that the overexpression of USP2 promoted the nuclear translocation of p53."
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"Although p53 can be activated robustly under both conditions, in contrast to Mdm2 inhibition, USP2 inhibition neither affects Mdm2 induction by p53 nor suppresses Mdm2-mediated repression of p53."
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"For example, USP2 and USP7 modulate p53 and MDM2, impacting cell survival and tumor development, while USP22 stabilizes c-Myc, driving cancer proliferation and metastasis [9–13]."
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"Therefore, we speculate that USP2 overexpression may lower the ubiquitination levels of p53 by acting on the K305R site of p53 protein and promote the translocation of p53 from the cytoplasm to the nucleus."
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