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Morpholine activates KCNH2. 2 / 2

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"Replacement of piperidine with morpholine (as in 5g ) decreased hERG inhibitory activity (IC 50 >10 μM), however this change resulted in 5-fold less potent MCH1R binding affinity than 5c ."

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"Synergy with geldanamycin was also observed between the allylamine terbinafine (FIC 90 = 0.25), which targets Erg1, and the morpholine fenpropimorph (FIC 90 = 0.016), which targets Erg24 and Erg2 (XREF_FIG)."

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IndraLab

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Morpholine activates KCNH2. 2 / 2

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