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OTUB2 deubiquitinates KRT80. 3 / 3
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"In conclusion, KRT80 is deubiquitinated by OTUB2, which activates the PI3K/AKT pathway that promotes gastric cancer cell proliferation and growth; KRT80 is essential in this process (Figure 1)."
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"Studies have reported that OTUB2 facilitates cancer metastasis via activating YAP and TAZ [36] and enhances the proliferation of gastric cancer cells by deubiquitinating KRT80 [37]."
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"Ouyang et al found that KRT80 is deubiquitinated by OTUB2 to activate the PI3K/AKT pathway, which promotes the growth and proliferation of GC cells; KRT80 is essential in this process."
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