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Caffeine inhibits FOS. 2 / 3
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"Co-administration of the A2a receptor antagonist 8-(3-chlorostyryl) caffeine (5 mg/kg) with quinpirole (0.05 mg/kg) also attenuated striatal c-Fos induction following reserpine to a greater extent than 0.05 mg/kg quinpirole alone."
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"Among rats exposed to an acute caffeine challenge, chronic caffeine treatment decreased numbers of c-Fos (PC-38)-ir/Tph2-immunonegative cells within the DRD at -7.46 mm bregma in addition to the DRV at every rostrocaudal level studied."
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