IndraLab

Statements


USP10 deubiquitinates CDKN2A. 3 / 3
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"Additionally, USP10 and USP4 deubiquitinate p14ARF—a product of the INK4/ARF locus—which antagonizes MDM2 to enhance p53 stability [102, 103]."

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"USP10, in turn, mediated the deubiquitination of p14ARF, preventing its proteasome dependent degradation."

"Oncogene-induced senescence mediated by c-Myc requires <span class="match term0">USP10</span> dependent deubiquitination and stabilization of <span class="match term1">p14ARF</span>"