IndraLab

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USP10 increases the amount of SIRT6. 7 / 7
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"Sirt6 expression was increased by USP10 overexpression, however, this effect was counteracted by interference with Sirt6 (Fig. 8D)."
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"Moreover, gain-function studies revealed that USP10 overexpression led to an increase in Sirt6 protein level (Fig. 8B)."
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"Conversely, shRNA mediated knockdown of USP10 decreased the endogenous SIRT6 protein levels without affecting SIRT6 mRNA levels (XREF_FIG)."
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"USP10 overexpression increased SIRT6 protein expression (S5 Fig) while USP10 knockdown had the opposite effect (S6 Fig)."
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"Western blot assay showed that LPS resulted in decreased Sirt6 and increased Nrf2 and HO-1 levels, whereas USP10 overexpression led to an increased expression of Sirt6, Nrf2 and HO-1 in HK-2 cells induced by LPS (Fig. 6 A)."
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"Furthermore, our results demonstrated that USP10 overexpression increased Sirt6, Nrf2 and HO-1 levels, but were reduced following Sirt6 knockdown (Fig. 6B)."
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"It was shown that knockdown of USP10 decreased Sirt6 expression, whereas overexpression of USP10 increased Sirt6 protein expression in primary cardiomyocytes after Ang II stimulation."
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