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USP22 activates ABCC1. 6 / 6
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"The downregulation of USP22 suppresses multidrug resistance-associated protein 1 ( MRP1 ) to induce intracellular sorafenib accumulation and hampers glycolysis of HCC cells ."
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"] Downregulation of USP22 could inhibit the AKT / GSK-3beta pathway and further suppress the expression of MRP1 ( Figure 4a [ ."
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"] Our study provided strong evidence that the downregulation of USP22 by Gal-SLPs suppressed the expression of MRP1 and caused high intracellular sorafenib accumulation ."
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"In our previous study , USP22 bound to SIRT1 and subsequently activated the AKT pathway , increasing the expression of MRP1 to induce 5-FU resistance in HCC cells [ 15 ] ."
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"iv ) The downregulation of USP22 not only suppresses multidrug resistance-associated protein 1 ( MRP1 ) , enhances the intracellular accumulation of sorafenib , and finally inhibits cell proliferation and cancer angiogenesis , but also inhibits glycolysis in hepatocellular carcinoma ( HCC ) cells , enhancing sorafenib chemosensitivity and impairing cell metabolism ."
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"During sorafenib treatment , upregulation of USP22 increases ABCC1 expression and subsequently contributes to sorafenib resistance in HCC cells ."
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