IndraLab

Statements

USP22 activates ABCC1. 11 / 11
| 6 5
reach
"Simply put, USP22 may activate the SIRT1–AKT–MRP1 pathway and consequently promote MDR in human HCC cells (226)."
31608282
eidos
"The downregulation of USP22 suppresses multidrug resistance-associated protein 1 ( MRP1 ) to induce intracellular sorafenib accumulation and hampers glycolysis of HCC cells ."
33717848
reach
"Similarly, overexpression of USP22 in BEL/7402 cells activated the AKT and MRP1 pathway."
28417539
eidos
"iv ) The downregulation of USP22 not only suppresses multidrug resistance-associated protein 1 ( MRP1 ) , enhances the intracellular accumulation of sorafenib , and finally inhibits cell proliferation and cancer angiogenesis , but also inhibits glycolysis in hepatocellular carcinoma ( HCC ) cells , enhancing sorafenib chemosensitivity and impairing cell metabolism ."
33717848
reach
"Both of these findings indicated that USP22 upregulated MRP1 depending on the AKT pathway."
28417539
reach
"3.5 USP22 activates the AKT and MRP1 pathway depending on SIRT1 in HCC cells."
28417539
reach
"XREF_FIG A, knockdown of USP22 by shRNA inhibited the AKT and MRP1 pathway compared with control shRNA cells and wild-type cells."
28417539
eidos
"] Our study provided strong evidence that the downregulation of USP22 by Gal-SLPs suppressed the expression of MRP1 and caused high intracellular sorafenib accumulation ."
33717848
eidos
"During sorafenib treatment , upregulation of USP22 increases ABCC1 expression and subsequently contributes to sorafenib resistance in HCC cells ."
35203285
eidos
"] Downregulation of USP22 could inhibit the AKT / GSK-3beta pathway and further suppress the expression of MRP1 ( Figure 4a [ ."
33717848
eidos
"In our previous study , USP22 bound to SIRT1 and subsequently activated the AKT pathway , increasing the expression of MRP1 to induce 5-FU resistance in HCC cells [ 15 ] ."
31587155