IndraLab

Statements

USP9X inhibits Notch. 3 / 3
| 3
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"Of note, the meta-analysis of the published transcriptomics datasets highlighted potential dysregulation of upstream regulators able to activate (MECOM and USP9X) [50,51] or inhibit Notch (e.g., ARRB1) [52]."
| PMC
reach
"The pharmacological inhibition of USP9x using G9, a partially selective, small-molecule USP9x inhibitor, reduced Notch activity, remodeled the tumor immune landscape, and reduced tumor growth without associated toxicity."
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reach
"Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer."
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