IndraLab

Statements

Azithromycin inhibits TLR7. 4 / 4
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"Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod induced psoriasis like skin inflammation in mice."
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"In another study, Huang et al found that azithromycin inhibits TLR7 signaling in dendritic cells and improves the imiquimod-induced Psoriasis-like cutaneous inflammation in mice 19 ."
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"At the same time , hydroxychloroquine and azithromycin inhibit TLR7 / 8 signaling [ 92 ] , [ 93 ] Selective interference of PD-1 / PDL-1 pathway with antagonistic antibodies against PD-1 receptor reduces type I IFN response and ISG expression in chronic HIV infection [ 31 ] , [ 32 ] , [ 33 ] ."
| PMC
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"Azithromycin inhibited lysosomal acidification and the proteolytic processing of TLR7, thereby blocking imiquimod induced NF-kappaB and IRF7 activation in DCs [XREF_BIBR]."
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