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OTUD3 increases the amount of IFNB1. 2 / 2
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"Additionally, knockdown of OTUD3 in HFF cells enhanced SeV- and EMCV-induced IFNB1 and IL6 expression, whereas the ectopic expression of OTUD3 suppressed the SeV- and EMCV-induced IFNB1 and IL6 expres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Furthermore, the reconstitution of Otud3 , but not Otud3 (C76A), in Otud3 -deficient MEFs induced the transcription of the downstream genes Ifnb1 , Isg56 , Cxcl10 , and Il6 upon HSV-1 infection ( Figu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"