IndraLab

Statements

Baicalin inhibits CASP1. 6 / 6
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"Zhang et al. reported that baicalin (20 and 40 mg/kg bodyweight) suppressed CUMS-induced hippocampal apoptosis and inflammatory cytokines (Casp1 and IL-1β) and upregulated DCXcx, Eno2, and Bdnf in the hippocampus."
37764277
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"Whereas, hyperphosphorylation of NF-κB p65 and enhanced expression of NLRP3 inflammasome and its products, Caspase-1 and IL-1β, were suppressed by baicalin in a dose-dependent manner."
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"At the protein level, we found that baicalin could significantly increase the production of NLRP6 and decrease the production of caspase-1 (Figures 4(e)–4(g))."
36016685
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"Baicalin (BA), a natural flavone, reduced hepatic NLRP3 inflammasome components, NLRP3 and caspase-1, which activate interleukins (IL), measured as IL-1."
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"On the contrary, baicalin treatment could either inhibit the formation of ASC specks in immunofluorescence or decrease the NLRP3, ASC, pro-caspase-1 in a dose dependent manner."
29163427
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"In line with the results derived from ATP stimulation, baicalin also markedly reduced caspase-1 activation and mature IL-1beta secretion in a dose dependent manner upon nigericin stimulation, indicating the suppression of NLRP3 activation."
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