IndraLab

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"In line with the results derived from ATP stimulation, baicalin also markedly reduced caspase-1 activation and mature IL-1beta secretion in a dose dependent manner upon nigericin stimulation, indicating the suppression of NLRP3 activation."

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"On the contrary, baicalin treatment could either inhibit the formation of ASC specks in immunofluorescence or decrease the NLRP3, ASC, pro-caspase-1 in a dose dependent manner."