IndraLab

Statements

Ceramide activates KCNH2. 3 / 3
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"These aberrant electrophysiological changes could be due to de novo ceramide synthesis, and ceramide induced HERG depression leading to arrythmias and heart failure in DCM."
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"Chapman et al. confirmed that ceramide induced modification of HERG currents and an associated rapid decline in HERG protein can be caused by protein ubiquitinylation and subsequent lysosomal degradation [XREF_BIBR]."
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"Besides, it has been demonstrated that hERG is negatively modulated by hyperglycemia, tumor necrosis factor, ceramide and reactive oxygen species which are cellular metabolites accumulated in diabetic tissues [XREF_BIBR, XREF_BIBR]."
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