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USP2 activates apoptotic process. 9 / 12
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"USP2 Plays an Important Role in TRAIL-Mediated Apoptosis ."
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"Significantly , siRNA knockdown of USP2 resulted in apoptosis , which could be reversed by overexpression of fatty acid synthase ( FAS ) ( 8) ."
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"These data collectively suggest that the USP2 plays a critical role in the proliferation and survival of MM cells in vitro and in vivo.3.8 GA induces the apoptosis of MM cells by targeting USP2 and destabilizing KRAS."
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"We have previously shown that the 41 kDa USP2 isoform induces apoptosis [3] and that the 69 kDa USP2a isoform mediates the apoptosis signal of the TNF receptor [5]."
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"Caspase dependent apoptosis caused by overexpression of USP2 was first described for USP2-2 [XREF_BIBR] but also for isoform 1 [XREF_BIBR]."
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"Knockdown of USP2 did not increase cell apoptosis in Hut-78 cells compared to cells with control siRNA, further suggesting the pivotal role of p53 in USP2 function."
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"Our studies indicate that apoptosis can be modulated by peroxisomal import of USP2, resulting in its spatial separation from its target proteins in the cytosol and nucleus."
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"In vitro an artificial knockdown of USP2 inhibited actinomycin D/TNFalpha induced hepatocyte apoptosis, which was associated with elevated levels of the anti-apoptotic protein c-Flip (L/S) and a concomitant decrease of cellular levels of the ubiquitinligase Itch, a negative regulator of c-Flip."
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"Hence, the USP2 variants seem to cause the activation of apoptosis pathways by the specific stabilising of their RIP1 substrate.Based on the pro apoptotic effect when USP2c was targeted by RNAi, we fo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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