IndraLab

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OTUD3 inhibits cell population proliferation. 13 / 13
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"OTUD3 inhibits BC cell proliferation and makes BC cells more sensitive to chemotherapeutic drug-induced apoptosis by directly interacting with p53 through the amino-terminal OTU region to deubiquitinate it from murine double minute 2 (Mdm2)-mediated ubiquitination and degradation (Pu et al., 2020)."
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"OTUD3 inhibits cell proliferation."
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"Compared to the control cells, knockdown of endogenous OTUD3 by shRNA in the MCF7 and DU4475 cells increased the cell proliferation rate."
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"OTUD3 could rescue the accelerated cell proliferation caused by OTUD3 knockdown, but the inactive enzyme mutant OTUD3 could not inhibit the accelerated cell proliferation, indicating that regulation of the effect of OTUD3 on cell proliferation depends on its ubiquitinase activity (Fig. 6b)."
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"3.6 OTUD3 suppressed proliferation and growth of HeLa by downregulating the mTORC1."
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"These data suggest that OTUD3 can inhibit BC cell proliferation."
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"Furthermore, OTUD3 silence promoted proliferation and motility and decreased apoptosis for HCT116 cells and restored partly miR-32-mediated cell proliferation, migration, and antiapoptosis for colon cancer."
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"MiR-32 also inhibits the expression of OTUD3 and promotes cell proliferation and motility and inhibits apoptosis in colon cancer cells (Jin et al., 2019)."
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"Restoration of YY1 expression weakened the OTUD3 knockdown-induced suppression of CRC proliferation (Fig. 4A, B)."
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"These experiments collectively confirmed that OTUD3 can suppress the growth and proliferation of tumor cells.Moreover, to corroborate these findings, we conducted CCK8 cell proliferation assays on HeLa-WT, OTUD3-GFP, OTUD3-KO, OTUD3-KO cells with exogenous expression of wild-type OTUD3 (OTUD3-KO+OTUD3-Myc), and OTUD3-KO cells with exogenous expression of catalytically inactive OTUD3 (OTUD3-KO+OTUD3-C76A-Myc)."
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"The results revealed that stable expression of OTUD3 inhibited HeLa cell proliferation, OTUD3 knockout promoted proliferation, and reintroduction of wild-type OTUD3 into OTUD3-KO cells restored the enhanced proliferation ability."
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"3.7 OTUD3 suppressed proliferation and growth of HeLa by downregulating mTOR signaling mediated cell metabolism."
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"These results collectively support OTUD3’s ability to suppress tumor cell growth and proliferation through the downregulation of the mTOR signaling pathway."
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